In his seminal new book, The Disordered Mind (Farrar, Straus & Giroux, 2018), Eric Kandel, winner of the Nobel Prize in Physiology or Medicine, draws on a lifetime of path-breaking research and the work of many other leading neuroscientists to take us on an unusual tour of the brain. He confronts one of the most difficult questions science faces: How does our mind, our individual sense of self, emerge from the physical matter of the brain? The brain’s 86 billion neurons communicate with one another through very precise connections. But sometimes these connections are disrupted. As a result, the brain processes that give rise to our mind can become disordered, resulting in devastating diseases that haunt humankind: autism, depression, bipolar disorder, schizophrenia, Alzheimer’s disease, Parkinson’s disease, and PTSD. While these disruptions bring great suffering, they can also reveal the mysteries of how the brain produces our most fundamental experiences and capabilities. Our study group will follow Kandel’s explorations: how brain processes become disordered; how learning about these disordered processes is essential for finding new treatments; for improving our understanding of the normal workings of the brain, and for deepening our understanding of thought, feeling, behavior, memory, and creativity.